Опасен ли е прекомерният прием на витамин Д?

Витамин Д е мастноразтворим витамин. Това означава, че той може да се натрупва в човешкото тяло и при много високи количества да се стигне дори до интоксикация [1,2]. Токсичното въздействие на витамин Д причинява неспецифични симптоми като загуба на тегло, полиурия и сърдечни аритмии. Освен това е възможна хиперкалциемия, която да доведе до калцификация на съдовете и тъканите с последващо увреждане на сърцето, кръвоносните съдове и бъбреците [3].

Коя е горната граница на безопасен прием?

Горната граница на прием на витамин Д за възрастни, определена от Националната медицинска академия на САЩ, е 4000 IU/ден (международни единици/ден). Счита се, че това е максималното ниво на ежедневна консумация без необходим медицински контрол, което може да се приема цял живот без да причинява странични ефекти [3,4].

Опасен ли е прием на витамин Д по-голям от 4000 IU/ден?

Най-високото ниво, за което няма информация за странични ефекти от изследвания, е 10 000 IU/ден (No Observed Adverse Effects Level), т.е. до това ниво на прием появата на симптоми на витамин Д токсичност са малко вероятни [1,3,4,5]. Липсата на странични ефекти при клинични проучвания, правени с дози до 10 000 IU, e причина някои учени да смятат, че именно това ниво трябва да бъде възприето като горна граница на прием [5].

Съществуват доказателства, че при дневен прием между 40 000 и 100 000 IU (1000-2500 mcg) в продължение на един или няколко месеца се стига до интоксикация [1,6]. Това количество представлява 10 до 25 пъти повече от препоръчваната горна граница за прием.

Как се разбира, че е приет прекалено голямо количество витамин Д?

Високи нива на витамин Д в кръвта могат да се натрупат при следните два случая [2]:

1)  Ежедневен прием на повече от 10 000 IU/ден в продължение на три или повече месеца. До интоксикация обаче е по-вероятно да се стигне при ежедневен прием на дози над 40 000 IU/ден в продължение на три или повече месеца.

2)   Прием на повече от 300 000 IU за период от 24 часа.

Източници

[1] How Much Vitamin D is Too Much? Authority Nutrition, < https://www.healthline.com/nutrition/how-much-vitamin-d-is-too-much#section1>

[2] Am I getting too much vitamin D? Vitamin D Council, < https://www.vitamindcouncil.org/about-vitamin-d/am-i-getting-too-much-vitamin-d/>

[3] Vitamin D. Fact Sheet for Health Professionals. National Institutes of Health, <https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h8>

[4] What is the upper limit and NOAEL and are they justified? Vitamin D Council, <https://www.vitamindcouncil.org/what-is-the-upper-limit-and-noael-and-are-they-justified/>

[5] Hathcock, J., N. et al. Risk assessment for Vitamin D. American Journal of Clinical Nutrition, 2007, <http://ajcn.nutrition.org/content/85/1/6.long>

[6] Koul, P., A. et. al. Vitamin D Toxicity in Adults: A Case Series from an Area with Endemic Hypovitaminosis D. Oman Medical Journal, 2011, < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191699/>

Categories: Supplements

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marewil · June 8, 2022 at 7:23 pm

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odwisavi · June 8, 2022 at 7:47 pm

In addition, it allows you to crop and resizing images and supports S3, FTP and HTTP based image resources.

This is a tool to help Windows application developers and designers improve their development efficiency and reach greater productivity in their development work.

Catch and transform the errors right in the Build process.
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wanisl · June 8, 2022 at 8:13 pm

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xilemar · June 8, 2022 at 8:39 pm

Once downloaded, they will be ready to use in any context. Add animated emoticons as status messages, display on your blog, or use on your website, block your browser or instant messenger!

The Mojicon Dispenser for the Microsoft Windows-based operating systems runs on Microsoft® Windows® 6.1 and higher.

Signed releases can be downloaded from the applications page below.

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eliwall · June 8, 2022 at 9:04 pm

Colosseum
· Sierpinski Triangle
· Sierpinski Hexagon
· Poisson Sieve
· Fractal Tree
· Spiral Branch
· Binomial Spiral
· Boolean Spiral
· Composite Spiral
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lankelsa · June 8, 2022 at 9:29 pm

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kellata · June 8, 2022 at 10:12 pm

Simple to use
In the end, Snapshot Magic’s rather straightforward interface might put you off, as you will have to press the mouse button at the desired point, rather than having it triggered by a keyboard shortcut. It is also worth mentioning that while you can activate the feature from the tool’s main window, there are also options to start Snapshot Magic from the desktop icon and have it automatically take care of the capturing without the need to press the mouse button.
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ranaquy · June 8, 2022 at 11:01 pm

Typing Step by Step 2.4.1
Homepage:

Ping Pong Master is a fun and easy to play game that combines both strategy and dexterity.
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shayosh · June 9, 2022 at 5:00 am

Written by Chris Lattner.

* Some corrections:

v2.38 22 Jul 2013

Added support for NADS_LOOP_REPEAT

v2.37 28 Feb 2013

NEW: dbregex can take a filename as input

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borolati · June 9, 2022 at 6:15 pm

It sports a neat and intuitive graphical interface with many tools at hand and it is easy to use. Homeopathy is available for Windows operating systems.

Frogatto is a specialized drag and drop game with unique gameplay mechanics, most of which have not been seen in any other indie game. You are challenged to make puzzles as you move through levels, while collecting as many frogs as possible. Frogatto is visually stunning and simple to learn, yet with plenty of depth to conquer.
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